Allopurinol and endothelial function in heart failure: future or fantasy?
نویسندگان
چکیده
Allopurinol and Endothelial Function in Heart Failure : Future or Fantasy? Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000024270.37833.F9 2002;106:173-175 Circulation. http://circ.ahajournals.org/content/106/2/173 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
اثرات درمانی آلوپورینول بر عملکرد بطن چپ در بیماران مبتلا به نارسایی مزمن قلب
Introduction & Objective: Heart failure that is a major health problem with increasing incidence with the aging of the population often occurs as a result of ischemia and coronary artery disease. Allopurinol can protect the ischemic heart muscle and improve the use of energy during myocardial ischemia. The aim of the present study was to evaluate the effects of allopurinol on the left ventric...
متن کاملAllopurinol improves endothelial dysfunction in chronic heart failure.
BACKGROUND Increased oxidative stress in chronic heart failure is thought to contribute to endothelial dysfunction. Xanthine oxidase produces oxidative stress and therefore we examined whether allopurinol improved endothelial dysfunction in chronic heart failure. METHODS AND RESULTS We performed a randomized, placebo-controlled, double-blind crossover study on 11 patients with New York Heart ...
متن کاملHigh-Dose Allopurinol Improves Endothelial Function by Profoundly Reducing Vascular Oxidative Stress and Not by Lowering Uric Acid
Background—Allopurinol has been shown to improve endothelial function in chronic heart failure. This study aimed to establish its mechanism of action and to construct a dose–response curve for the effect of allopurinol. Methods and Results—Two randomized, placebo-controlled, double-blind, crossover studies were performed for 1 month on patients with New York Heart Association Class II–III chron...
متن کاملLetter by Kielstein et al regarding article, "High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid".
BACKGROUND Allopurinol has been shown to improve endothelial function in chronic heart failure. This study aimed to establish its mechanism of action and to construct a dose-response curve for the effect of allopurinol. METHODS AND RESULTS Two randomized, placebo-controlled, double-blind, crossover studies were performed for 1 month on patients with New York Heart Association Class II-III chr...
متن کاملAllopurinol reduces B-type natriuretic peptide concentrations and haemoglobin but does not alter exercise capacity in chronic heart failure.
OBJECTIVE To study whether the effect of allopurinol on improvement of endothelial dysfunction in chronic heart failure (CHF) translates into improved exercise capacity and to examine whether allopurinol also improves B-type natriuretic peptide (BNP), the other important prognostic marker of CHF. DESIGN Randomised, double blind, placebo controlled crossover trial. SETTING Teaching hospital....
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عنوان ژورنال:
- Circulation
دوره 106 2 شماره
صفحات -
تاریخ انتشار 2002